INTRODUCING:
AffiBio-UIA™
Utilizing unique and proprietary algorithms that are derived from a computer-assisted libraries of amino acid combinations and substitutions. AffiBio-UIA™ generates amino acid sequences that are Cold Chain Free™.
Background
Proteins, specifically antibody proteins, have to be refrigerated to maintain their efficacy whether for diagnostic or therapeutic applications.
“Cold-Chain” is often the recommended temperature-controlled supply chain, from the point of manufacture to the end-user. Freezers, coolers, warehouse and working room HVAC systems, transportation vehicles, and incremental utility expenses are examples of the cold-chain handling system necessary to assure a product’s efficacy. When any part of the cold-chain continuum lapses, products must be destroyed since performance is risked.
“Cold-Chain” is often the recommended temperature-controlled supply chain, from the point of manufacture to the end-user. Freezers, coolers, warehouse and working room HVAC systems, transportation vehicles, and incremental utility expenses are examples of the cold-chain handling system necessary to assure a product’s efficacy. When any part of the cold-chain continuum lapses, products must be destroyed since performance is risked.
The Challenge
The Biopharma industry using temperature-sensitive drugs, vaccines, diagnostics, and blood products, is enjoying strong growth in product development and expanding market sales. Yet, the industry is confronted with rising cost pressures from payers worldwide. It costs more to keep products at refrigerated or at frozen temperatures than it does to keep them at uncontrolled ambient (room temperature) conditions. There is more to pack and transport them cold, and more to be able to demonstrate by process qualification or by measurement of each shipment that the products stay cold.
Our Approach
StableBody Technologies LLC has created an elegantly simple, yet incredibly powerful method to solve this problem. The SBT Rational Protein Design Method, AffiBio-UIA™, utilizes a set of unique and proprietary algorithms that are derived from a computer-assisted libraries of amino acid combinations and substitutions. When these combinations and substitutions are rearranged systematically, AffiBio-UIA™ generates amino acid sequences for structurally and functionally improved antibody proteins, that are Cold Chain Free™.
The Results
AffiBio-UIA™, uses computational biology and bioinformatics to design thermodynamic optimized antibody sequences. By analyzing large datasets of antibody sequences and patterns, features are identified that are associated with highly effective antibodies. This information is used to design antibodies that are more stable, effective and efficient than the predecessor antibody.
High-performance computing
Innovative, proprietary algorithms
Data mining capabilities
Intuitive interface(s)
Faster results than ever before
Limited shelf life, requiring cold storage
Temperature, chemical, and enzyme degradation at ambient conditions, and reduced performance over time
Temperature, chemical, and enzyme degradation at ambient conditions, and reduced performance over time
Lot-to-lot variability in manufacturing
Reproducibility issue
Reproducibility issue
Future of Protein Engineering
Unmet Need:
Adapt & Optimize Antibodies for New Applications
Adapt & Optimize Antibodies for New Applications
StableBody Technologies, LLC offers genome-based, proprietary strategies for antibody optimization
Protein structural modeling and synthetic biochemistry improve stability and affinity profiles
Improved protein function and structure offer competitive advantages
Increased thermal stability extends product shelf life, reduces need for cold chain storage
AffiBio-UIA™ confers robustness, reduces R&D costs, decreases product failure, development times, and increases production scale-up
