Cold-Chain Logistics is a Thing of the Past!
Utilizing unique and proprietary algorithms that are derived from a computer-assisted libraries of amino acid combinations and substitutions. AffiBio-UIA™ generates amino acid sequences that are Cold-Chain Free™.
Increased performance and manufacturing
Longer shelf-life, storage and distribution
Proteins, specifically antibody proteins, have to be refrigerated to maintain their efficacy whether for diagnostic or therapeutic applications.
“Cold-Chain” is often the recommended temperature-controlled supply chain, from the point of manufacture to the end-user. Freezers, coolers, warehouse and working room HVAC systems, transportation vehicles, and incremental utility expenses are examples of the cold-chain handling system necessary to assure a product’s efficacy. When any part of the cold-chain continuum lapses, products must be destroyed since performance is risked.
The Biopharma industry using temperature-sensitive drugs, vaccines, diagnostics, and blood products, is enjoying strong growth in product development and expanding market sales. Yet, the industry is confronted with rising cost pressures from payers worldwide. It costs more to keep products at refrigerated or at frozen temperatures than it does to keep them at uncontrolled ambient (room temperature) conditions. There is more to pack and transport them cold, and more to be able to demonstrate by process qualification or by measurement of each shipment that the products stay cold.
StableBody Technologies, LLC has created an elegantly simple, yet incredibly powerful method to solve this problem. The SBT Rational Protein Design Method, AffiBio-UIA™, utilizes a set of unique and proprietary algorithms that are derived from a computer-assisted libraries of amino acid combinations and substitutions. When these combinations and substitutions are rearranged systematically, AffiBio-UIA™ generates amino acid sequences for structurally and functionally improved antibody proteins, that are Cold-Chain Free™.
Antibody proteins fragile in even ambient conditions
Limited shelf life, requiring cold storage.
Temperature, chemical, and enzyme degradation at ambient conditions, and reduced performance over time.
Antibody protein function nearly impossible to predict
Lot-to-lot variability in manufacturing.
AffiBio-UIA™, uses computational biology and bioinformatics to design thermodynamic optimized antibody sequences. By analyzing large datasets of antibody sequences and patterns, features are identified that are associated with highly effective antibodies. This information is used to design antibodies that are more stable, effective and efficient than the predecessor antibody.
Innovative, proprietary algorithms
Data mining capabilities
Faster results than ever before
Future of Protein Engineering
Adapt & Optimize Antibodies for New Applications
StableBody Technologies, LLC offers genome-based, proprietary strategies for antibody optimization.
Protein structural modeling and synthetic biochemistry improve stability and affinity profiles.
Improved protein function and structure offer competitive advantages.
Increased thermal stability extends product shelf life, reduces need for cold-chain storage.
AffiBio-UIA™ confers robustness, reduces R&D costs, decreases product failure, development times, and increases production scale-up.
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4675 Signature Drive
Middleton, WI 53562