Experts in neuroscience, software engineering, protein engineering, microbiology, data management, project management, and finance, with over 100 years of combined experience
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FACT: Proteins, specifically antibody proteins, have to be refrigerated to maintain their efficacy whether for diagnostic or therapeutic applications.
Currently, there is no known protein amino acid sequence alignment user interface tool known that is available for every-day scientists to solve thermal stability problems leading to improved affinity performance of antibody proteins.
StableBody Technologies, LLC is offering its rational protein design technology as a User Interface Application for scientists everywhere working with amino acid sequence alignment data in protein design and engineering from their lab bench base with built-in automation components for design work.
Our Core Rational Protein Design Method AffiBio-UIA™:
The Universal Rational Biodesign of Antibody Proteins Using Proprietary Thermodynamic Stabilization Algorithms
Stablebody Technologies, LLC has developed an elegantly simple, rapid, and cost- effective method to design, engineer, and produce large numbers of structurally and functionally improved proteins. This is not a high throughput screening approach but a rational, focused, and computational approach producing calculable, rapid and robust improvements.
Can improve antibody protein binding properties for higher sensitivity and specificity!
Can improve antibody protein thermodynamic stability to eliminate cold chain requirements for shipping and storage!
Can improve antibody protein purification and production yields and timelines!
Can improve research, development, regulatory and manufacturing timelines!
Can improve product to market timelines!
“Cold-Chain” is often the recommended temperature-controlled supply chain, from the point of manufacture to the end-user. Freezers, coolers, warehouse and working room HVAC systems, transportation vehicles, and incremental utility expenses are examples of the cold-chain handling system necessary to assure a product’s efficacy. When any part of the cold-chain continuum lapses, products must be destroyed since performance is risked.
The Biopharma industry using temperature-sensitive drugs, vaccines, diagnostics, and blood products, is enjoying strong growth in product development and expanding market sales. Yet, the industry is confronted with rising cost pressures from payers worldwide. It costs more to keep products at refrigerated or at frozen temperatures than it does to keep them at uncontrolled ambient (room temperature) conditions. There is more to pack and transport them cold, and more to be able to demonstrate by process qualification or by measurement of each shipment that the products stay cold.
Proteins are governed by laws of thermodynamic principles. Using these principles to predict protein structure/function has been neglected in the past because of the vast complexity of thermodynamic properties. These properties have near-infinite conformational possibilities in proteins.
StableBody Technologies, LLC has created an elegantly simple, yet incredibly powerful method to solve this problem. The SBT Rational Protein Design Method, AffiBio-UIA™, utilizes a set of unique and proprietary algorithms that are derived from a computer-assisted libraries of amino acid combinations and substitutions. When these combinations and substitutions are rearranged systematically, AffiBio-UIA™ generates amino acid sequences for structurally and functionally improved antibody proteins, that are Cold Chain Free™.
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2023 StableBody Technologies, LLC
4675 Signature Drive
Middleton, WI 53562